5 edition of Metal ions in gene regulation found in the catalog.
Includes bibliographical references and index.
|Statement||edited by Simon Silver, William Walden.|
|Contributions||Silver, S. 1936-, Walden, William, 1954-|
|LC Classifications||QP532 .M473 1998|
|The Physical Object|
|Pagination||ix, 473 p. :|
|Number of Pages||473|
|LC Control Number||97004469|
We have identified the fluoride ion binding site in the F o − F c omit map for fluoride ion and assign all three metal ions coordinated to the fluoride ion, to Mg 2+ ions, based on observation Cited by: Simon SILVER of University of Illinois at Chicago, IL (UIC) | Read publications | Contact Simon SILVER Metal Ions in Gene Regulation. Book. Jan ; Genes for all metals - .
Certain enzymes need a metal ion for full l of metal ion often results in partial or total loss of enzyme activity may be restored by replacing the original metal ion. Some such metal ions are K+,Cu+,Fe2+,Mg2+,Mn2+,Ca2+,Cu2+,Zn2+,Fe3+ etc, Common metal ions which play a role in enzyme action are mentioned below: 1. The fundamental mechanisms involved in the Si-mediated heavy metal stress tolerance include reduction of metal ions in soil substrate, co-precipitation of toxic metals, metal-transport related gene regulation, chelation, stimulation of antioxidants, compartmentation of metal ions, and structural alterations in by:
9 / METALS IN MEDICINE for the treatment of genitourinary and head and neck tumors and ofrheumatoid arthritis, respectively. In addition, compounds of radioactive metal ions such as 99mTc and complexes of paramagnetic metals such as Gd(III) are now in wide spread use as imaging agents for the diagnosis of disease. Many patients admit. The following is a list of experimentally validated riboswitches, organized by ligand. Cobalamin riboswitch (also B element), which binds either adenosylcobalamin (the coenzyme form of vitamin B 12) or aquocobalamin to regulate cobalamin biosynthesis and transport of cobalamin and similar metabolites, and other genes.; cyclic AMP-GMP riboswitches bind the signaling .
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This book is a comprehensive treatment of the role of metal ions in gene regulation, and it will be of great utility for those doing basic biological and biomedical research. This book is a comprehensive treatment of the role of metal ions in gene regulation, and it will be of great utility for those doing basic biological and biomedical research.
show more Product details. About this book Introduction This is the first volume on the role of metal ions in regulating genes to focus not only on toxicity effects of metals but also on the role of metal ions in normal metabolisms, in both prokaryotes and in eukaryotes.
Providing a treatment of the role of metal ions in gene regulation, this book is intended for those doing basic biological and biomedical research. regulating genes to focus not only on toxicity eGects of metals but also on the role of metal ions in normal metabolisms, in both prokaryotes and in eukaryotes.
This book is a comprehensive treatment of the role of metal ions in gene regulation, and it will be of great utility for those doing basic biological and biomedical research. Softcover reprint of the original 1st ed. Read Metal Ions in Gene Regulation.
Metal Ions in Gene Regulation should prove an essential reference for all microbiologists, biochemists, bioinorganic chemists, and molecular biologists, especially those interested in gene regulation.
About this book Metal ions and metal complexes have long been recognized as critically important components of nucleic acid chemistry, both in regulation of gene expression and as promising therapeutic agents.
Metal ions in gene regulation book Natural biochemical processes are routinely being discovered in living cells that involve RNA. Some of these processes, such as RNA interference, are now being exploited for biotechnology and medicinal applications.
DNA has also proven in recent years to be more than a passive storehouse of information. For example, non-B-form DNA structures formed by G-rich DNA. Since the s, several small RNA motifs capable of chemical catalysis have been discovered.
These small ribozymes, composed of between approximately 40 and nucleotides, have been found to play vital roles in the replication of subviral and viral pathogens, as well as in gene regulation in prokaryotes, and have recently been discovered in noncoding eukaryotic by: Metal Ions in Biological Systems.
"Volume 35 covers the biological cycling of iron in oceans; the transport of iron in microorganisms, fungi, and plants; the roles and properties of siderophores; the regulation of iron transport and uptake in animals, plants, and microorganisms, and more. Metal ions in biology is an ever expanding area in science and medicine involving metal ions in proteins and enzymes, their biosynthesis, catalysis, electron transfer, metal ion trafficking, gene regulation and disease.
While X-ray crystallography has. Treatment of Hepa cells with 30 μM zinc resulted in a similar increase in the relative rate of MT-I gene transcription at 1 hr. Thus, regulation of the MT-I gene by H 2 O 2 is primarily a transcriptional response, as has been previously shown for metal i Cited by: Metal ions are essential for many reactions, but excess metals can be toxic.
In bacteria, metal limitation activates pathways that are involved in the import and mobilization of metals, whereas Cited by: For instance, ions such as Fe 2+ can bind to the hemoglobin and myoglobin protein to help transport oxygen to organs in the body.
Other metals like magnesium and copper act to stabilize the shapes of enzymes. However, there are some metal ions that are highly toxic in. The best examples of the regulation of gene expression by metals are iron and zinc.
In the case of iron, metal occupancy decreases the binding of a metal-regulatory binding protein to ferritin mRNA, allowing the translation of ferritin mRNA to increase while simultaneously increasing binding to transferrin receptor mRNA, which increases the degradation of mRNA (O'Halloran, Cited by: 1.
Structural and Catalytic Roles of Metal Ions in RNA describes metal ion-binding motives, methods to detect and characterize metal ion binding sites, and the role of metal ions in folding and catalysis.
It deals with diffuse metal ion binding, RNA quadruplexes, the regulation of riboswitches, metal ions and ribozymes, including artificial : Roy Harrison. Metal ions are required for many cellular functions, in addition to their roles in stabilizing nucleic acid structures, and their absence is deleterious to the cell.
However, inappropriately high intracellular concentrations of metal ions are also associated with cellular toxicity. Therefore, proper homeostasis mechanisms are paramount to cell survival, a task that can be daunting Cited by: Metals are essential cofactors for bio‐chemical processes, including oxidative phosphorylation, gene regulation and free‐radical homeostasis.
Abnormalities in metal ions concentration in organisms, lead towards the eco‐physiological hazards in the by: () Metallothionein-like genes and phytochelatins in higher plants. in Metal Ions in Gene Regulation.
eds Silver S, Walden W (Chapman & Hall, London), pp – Grill E. This raises the question, how cells maintain tight regulation of the metal ion quotas while avoiding the toxicity of extra free ions in the cell. This article and the many others in this book introduce a few of the chemical considerations, the metal receptors and the metal‐trafficking proteins that regulate the intracellular : Benjamin A.
Gilston, Thomas V. O'Halloran. Metallothionein (MT) gene expression in fish tissues has been useful to sub-lethal risk assessment as biomarker of exposure to metal ions in fishes inhabiting metal contaminated area.
To investigate metal inductions of Tilapia MT gene expression in vivo, Tilapia s were injected with different concentrations of heavy metals and tissues were then Cited by: Regulation of Tilapia metallothionein gene expression by heavy metal ions Article in Marine Environmental Research 58() August with 91 Reads How we measure 'reads'.Regulation of Tilapia metallothionein gene expression by heavy metal ions.